Pharmacological effects and Indications:
The rhizome of Curcuma longa has been used as a healer agent in the form of salve and ointment traditionally. It has been also used for bacterial and fungous infections such as tinea topically. Nowadays it is proved that these extra effects are related to antioxidant; anti-inflammatory, anti-microbial and anti-fungal effects of curcuminoids in curcuma longa rhizomes.
Topical Gel of Sinanomin:
Used as improver of inflammation, pain and wound in dermatological conditions due to burn, insect bites, injury and diabetic neuropathy.
It´s useful for skin sensitivity and inflammatory diseases such as itching, burning, Eczema, Psoriasis and Acne.
It is effective in relieving muscle and joint pain.
It is effective for alleviating of Gingivitis and Aphthous.
Mechanism of action:
The anti-inflammatory effect of curcumin is most likely mediated through its ability to inhibit cyclooxygenase-2 (COX-2), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS). COX-2, LOX, and iNOS are important enzymes that mediate inflammatory processes.
Curcumin has an important role in acceleration of wound healing and prevention of scar through inhibiting phosphorylase kinase enzyme and NFkB and TGFB with preventing reproduction of fibroblasts and decreasing inflammatory reactions.
